Binding of Antiphospholipid Antibodies to Discontinuous Epitopes on Domain I of Human β(2)-Glycoprotein I: Mutation Studies Including Residues R39 to R43

OBJECTIVE: Pathogenic antiphospholipid antibodies (aPL) bind the self antigen N-terminal domain (domain I) of β(2)-glycoprotein I (β(2)GPI), with residues G40–R43 being important. However, peptides homologous to other regions of domain I have also been shown to bind aPL. Furthermore, there are no pu...

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Main Authors: Ioannou, Yiannis, Pericleous, Charis, Giles, Ian, Latchman, David S., Isenberg, David A., Rahman, Anisur
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117024/
https://ncbi.nlm.nih.gov/pubmed/17195232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.22306
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