Oxidation of β2-glycoprotein I associates with IgG antibodies to domain I in patients with antiphospholipid syndrome

Domain I (DI) of beta-2-glycoprotein I (β(2)GPI) contains the immunodominant epitope for pathogenic antiphospholipid antibodies (aPL). DI is exposed in the linear form of the molecule but not in the circular form that comprises 90% of serum β(2)GPI. The majority of circulating β(2)GPI is biochemical...

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Publicado en:PLoS One
Main Authors: Raimondo, Maria Gabriella, Pericleous, Charis, Radziszewska, Anna, Borghi, Maria Orietta, Pierangeli, Silvia, Meroni, Pier Luigi, Giles, Ian, Rahman, Anisur, Ioannou, Yiannis
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648189/
https://ncbi.nlm.nih.gov/pubmed/29049363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186513
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