PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome

APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI). We previously showed that bacterially-express...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: McDonnell, Thomas C. R., Willis, Rohan, Pericleous, Charis, Ripoll, Vera M., Giles, Ian P., Isenberg, David. A., Brasier, Allan R., Gonzalez, Emilio B., Papalardo, Elizabeth, Romay-Penabad, Zurina, Jamaluddin, Mohammad, Ioannou, Yiannis, Rahman, Anisur
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204385/
https://ncbi.nlm.nih.gov/pubmed/30405613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02413
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