Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound

Despite intensive efforts in the search for small molecules with anti-cancer activity, it remains challenging to achieve both high effectiveness and safety, since many agents lack the selectivity to only act on cancer cells. The interface of two apoptotic proteins, myeloid cell leukemia-1 (Mcl-1) an...

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Udgivet i:Oncotarget
Main Authors: Liu, Jiyuan, Tian, Zhen, Zhou, Nan, Liu, Xueying, Liao, Chenyi, Lei, Beilei, Li, Jianing, Zhang, Shengyong, Chen, Hui
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589576/
https://ncbi.nlm.nih.gov/pubmed/28903337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17294
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