Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

BRD4 has emerged as an important factor in tumorigenesis by promoting the transcription of genes involved in cancer development. However, how BRD4 is regulated in cancer cells remains largely unknown. Here, we report that the stability and functions of BRD4 are positively regulated by prolyl-isomera...

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Pubblicato in:Oncogene
Autori principali: Hu, Xiangming, Dong, Shi-Hui, Chen, Jinjing, Zhou, Xiao Zhen, Chen, Ruichuan, Nair, Satish, Lu, Kun Ping, Chen, Lin-Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589477/
https://ncbi.nlm.nih.gov/pubmed/28481868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.137
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