Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

BRD4 has emerged as an important factor in tumorigenesis by promoting the transcription of genes involved in cancer development. However, how BRD4 is regulated in cancer cells remains largely unknown. Here, we report that the stability and functions of BRD4 are positively regulated by prolyl-isomera...

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Publicado en:Oncogene
Autores principales: Hu, Xiangming, Dong, Shi-Hui, Chen, Jinjing, Zhou, Xiao Zhen, Chen, Ruichuan, Nair, Satish, Lu, Kun Ping, Chen, Lin-Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589477/
https://ncbi.nlm.nih.gov/pubmed/28481868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.137
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