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The prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins
Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes. Such conformational changes represent a novel and tightly controlled signaling mechanism regulating a spectrum of protein activities in physi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3185210/ https://ncbi.nlm.nih.gov/pubmed/21852138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2011.07.001 |
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