The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α–induced priming of the NADPH oxidase in human neutrophils

Neutrophils play a key role in host defense by releasing reactive oxygen species (ROS). However, excessive ROS production by neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase can damage bystander tissues, thereby contributing to inflammatory diseases. Tumor necrosis factor-α (TN...

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Detalhes bibliográficos
Main Authors: Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Hayem, Gilles, Ciappelloni, Silvia, Raad, Houssam, Arabi Derkawi, Riad, Bournier, Odile, Kroviarski, Yolande, Zhou, Xiao Zhen, Malter, James S., Lu, Ping K., Bartegi, Aghleb, Dang, Pham My-Chan, El-Benna, Jamel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031377/
https://ncbi.nlm.nih.gov/pubmed/20956805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273094
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