Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91(phox)/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67(phox), and p47(phox)

Neutrophils generate microbicidal oxidants through activation of a multicomponent enzyme called NADPH oxidase. During activation, the cytosolic NADPH oxidase components (p47(phox), p67(phox), p40(phox), and Rac2) translocate to the membranes, where they associate with flavocytochrome b(558), which i...

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Main Authors: Raad, Houssam, Paclet, Marie-Hélène, Boussetta, Tarek, Kroviarski, Yolande, Morel, Françoise, Quinn, Mark T., Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel
Formato: Artigo
Idioma:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660639/
https://ncbi.nlm.nih.gov/pubmed/19028840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-114553
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