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Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids. CBR1 catalyzes the NADPH- dependent production of 20β-dihydrocortiso...

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Τόπος έκδοσης:	Sci Rep
Κύριοι συγγραφείς:	Morgan, Ruth A., Beck, Katharina R., Nixon, Mark, Homer, Natalie Z. M., Crawford, Andrew A., Melchers, Diana, Houtman, René, Meijer, Onno C., Stomby, Andreas, Anderson, Anna J., Upreti, Rita, Stimson, Roland H., Olsson, Tommy, Michoel, Tom, Cohain, Ariella, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M., Andrew, Ruth, Kenyon, Christopher J., Hadoke, Patrick W. F., Odermatt, Alex, Keen, John A., Walker, Brian R.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group UK 2017
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5587574/ https://ncbi.nlm.nih.gov/pubmed/28878267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10410-1
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Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

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