Carbonyl Reductase 1 Overexpression in Adipose Amplifies Local Glucocorticoid Action and Impairs Glucose Tolerance in Lean Mice

Glucocorticoids play a critical role in metabolic homeostasis. Chronic or excessive activation of the glucocorticoid receptor (GR) in adipose tissue contributes to metabolic disorders such as glucose intolerance and insulin resistance. Steroid-metabolising enzymes in adipose, such as 11β-HSD1 or 5α-...

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Bibliografske podrobnosti
izdano v:J Endocr Soc
Main Authors: Bell, Rachel, Villalobos, Elisa, Nixon, Mark, Miguelez-Crespo, Allende, Sharp, Matthew, Koerner, Martha, Allan, Emma, Denham, Scott, Lee, Patricia, Homer, Natalie, Walker, Brian, Morgan, Ruth
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Steroid Hormones and Receptors
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090251/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1639
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