OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA

Recombinant adeno-associated viral (rAAV) vectors for human gene therapy require efficient and economical production methods to keep pace with the rapidly increasing clinical demand. In addition, the manufacturing process must ensure high vector quality and biological safety. The OneBac system offer...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Gene Ther Methods
Hauptverfasser: Mietzsch, Mario, Hering, Henrik, Hammer, Eva-Maria, Agbandje-McKenna, Mavis, Zolotukhin, Sergei, Heilbronn, Regine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2017
Schlagworte:
Special Issue on Adeno-Associated Viral (AAV) Vectors:Production, Purification, and Beyond—Part 1Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586161/
https://ncbi.nlm.nih.gov/pubmed/28125901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2016.164
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