Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

Efforts to identify driver mutations in cancer have largely focused on genes, whereas non-coding sequences remain relatively unexplored. Here we develop a statistical method based on characteristics known to influence local mutation rate and a series of enrichment filters in order to identify distal...

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Publicado en:Nat Commun
Autores principales: D′Antonio, Matteo, Weghorn, Donate, D′Antonio-Chronowska, Agnieszka, Coulet, Florence, Olson, Katrina M., DeBoever, Christopher, Drees, Frauke, Arias, Angelo, Alakus, Hakan, Richardson, Andrea L., Schwab, Richard B., Farley, Emma K., Sunyaev, Shamil R., Frazer, Kelly A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585396/
https://ncbi.nlm.nih.gov/pubmed/28874753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00100-x
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