Identification of cancer driver genes based on nucleotide context

Cancer genomes contain large numbers of somatic mutations, but few of these mutations drive tumor development. Current approaches identify driver genes based on mutational recurrence, or they approximate the functional consequences of nonsynonymous mutations using bioinformatic scores. While passeng...

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Udgivet i:Nat Genet
Main Authors: Dietlein, Felix, Weghorn, Donate, Taylor-Weiner, Amaro, Richters, André, Reardon, Brendan, Liu, David, Lander, Eric S., Van Allen, Eliezer M., Sunyaev, Shamil R.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031046/
https://ncbi.nlm.nih.gov/pubmed/32015527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0572-y
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