Integrated molecular drivers coordinate biological and clinical states in melanoma

We performed harmonized molecular and clinical analysis on 1,048 melanomas and discovered markedly different global genomic properties among subtypes (BRAF, (N)RAS, NF1, Triple Wild-Type), subtype-specific preferences for secondary driver genes, and active mutational processes previously unreported...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Conway, Jake R., Dietlein, Felix, Taylor-Weiner, Amaro, AlDubayan, Saud, Vokes, Natalie, Keenan, Tanya, Reardon, Brendan, He, Meng Xiao, Margolis, Claire A., Weirather, Jason L., Haq, Rizwan, Schilling, Bastian, Hodi, F. Stephen, Schadendorf, Dirk, Liu, David, Van Allen, Eliezer M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054830/
https://ncbi.nlm.nih.gov/pubmed/33230298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00739-1
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