Integrated molecular drivers coordinate biological and clinical states in melanoma

We performed harmonized molecular and clinical analysis on 1,048 melanomas and discovered markedly different global genomic properties among subtypes (BRAF, (N)RAS, NF1, Triple Wild-Type), subtype-specific preferences for secondary driver genes, and active mutational processes previously unreported...

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Publicado en:Nat Genet
Autores principales: Conway, Jake R., Dietlein, Felix, Taylor-Weiner, Amaro, AlDubayan, Saud, Vokes, Natalie, Keenan, Tanya, Reardon, Brendan, He, Meng Xiao, Margolis, Claire A., Weirather, Jason L., Haq, Rizwan, Schilling, Bastian, Hodi, F. Stephen, Schadendorf, Dirk, Liu, David, Van Allen, Eliezer M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054830/
https://ncbi.nlm.nih.gov/pubmed/33230298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00739-1
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