Inherited DNA-Repair Defects in Colorectal Cancer

Colorectal cancer (CRC) heritability has been estimated to be around 30%. However, mutations in the known CRC-susceptibility genes explain CRC risk in fewer than 10% of affected individuals. Germline mutations in DNA-repair genes (DRGs) have recently been reported in CRC, but their contribution to C...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: AlDubayan, Saud H., Giannakis, Marios, Moore, Nathanael D., Han, G. Celine, Reardon, Brendan, Hamada, Tsuyoshi, Mu, Xinmeng Jasmine, Nishihara, Reiko, Qian, Zhirong, Liu, Li, Yurgelun, Matthew B., Syngal, Sapna, Garraway, Levi A., Ogino, Shuji, Fuchs, Charles S., Van Allen, Eliezer M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985280/
https://ncbi.nlm.nih.gov/pubmed/29478780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.01.018
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