RNF43 is frequently mutated in colorectal and endometrial cancers

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Giannakis, Marios, Hodis, Eran, Mu, Xinmeng Jasmine, Yamauchi, Mai, Rosenbluh, Joseph, Cibulskis, Kristian, Saksena, Gordon, Lawrence, Michael S., Qian, ZhiRong, Nishihara, Reiko, Van Allen, Eliezer M., Hahn, William C., Gabriel, Stacey B., Lander, Eric S., Getz, Gad, Ogino, Shuji, Fuchs, Charles S., Garraway, Levi A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283570/
https://ncbi.nlm.nih.gov/pubmed/25344691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3127
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