RNF43 is frequently mutated in colorectal and endometrial cancers

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with...

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Vydáno v:Nat Genet
Hlavní autoři: Giannakis, Marios, Hodis, Eran, Mu, Xinmeng Jasmine, Yamauchi, Mai, Rosenbluh, Joseph, Cibulskis, Kristian, Saksena, Gordon, Lawrence, Michael S., Qian, ZhiRong, Nishihara, Reiko, Van Allen, Eliezer M., Hahn, William C., Gabriel, Stacey B., Lander, Eric S., Getz, Gad, Ogino, Shuji, Fuchs, Charles S., Garraway, Levi A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283570/
https://ncbi.nlm.nih.gov/pubmed/25344691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3127
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