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Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ

Nosiheptide is a prototypal thiopeptide antibiotic, containing an indole side ring in addition to its thiopeptide-characteristic macrocylic scaffold. This indole ring is derived from 3-methyl-2-indolic acid (MIA), a product of the radical S-adenosylmethionine enzyme NosL, but how MIA is incorporated...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Ding, Wei, Ji, Wenjuan, Wu, Yujie, Wu, Runze, Liu, Wan-Qiu, Mo, Tianlu, Zhao, Junfeng, Ma, Xiaoyan, Zhang, Wei, Xu, Ping, Deng, Zixin, Tang, Boping, Yu, Yi, Zhang, Qi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585349/
https://ncbi.nlm.nih.gov/pubmed/28874663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00439-1
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