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Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ
Nosiheptide is a prototypal thiopeptide antibiotic, containing an indole side ring in addition to its thiopeptide-characteristic macrocylic scaffold. This indole ring is derived from 3-methyl-2-indolic acid (MIA), a product of the radical S-adenosylmethionine enzyme NosL, but how MIA is incorporated...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5585349/ https://ncbi.nlm.nih.gov/pubmed/28874663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00439-1 |
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