Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent

Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchym...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Frescas, David, Hall, Brandon M., Strom, Evguenia, Virtuoso, Lauren P., Gupta, Mahima, Gleiberman, Anatoli S., Rydkina, Elena, Balan, Vitaly, Vujcic, Slavoljub, Chernova, Olga B., Gudkov, Andrei V.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584871/
https://ncbi.nlm.nih.gov/pubmed/28650766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1339850
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires