Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent

Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchym...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Frescas, David, Hall, Brandon M., Strom, Evguenia, Virtuoso, Lauren P., Gupta, Mahima, Gleiberman, Anatoli S., Rydkina, Elena, Balan, Vitaly, Vujcic, Slavoljub, Chernova, Olga B., Gudkov, Andrei V.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584871/
https://ncbi.nlm.nih.gov/pubmed/28650766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1339850
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