Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mic...

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Gepubliceerd in:Aging (Albany NY)
Hoofdauteurs: Hall, Brandon M., Balan, Vitaly, Gleiberman, Anatoli S., Strom, Evguenia, Krasnov, Peter, Virtuoso, Lauren P., Rydkina, Elena, Vujcic, Slavoljub, Balan, Karina, Gitlin, Ilya, Leonova, Katerina, Polinsky, Alexander, Chernova, Olga B., Gudkov, Andrei V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993332/
https://ncbi.nlm.nih.gov/pubmed/27391570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100991
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