Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4

Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor β) is one of the major profibrotic cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an ess...

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Publié dans:Autophagy
Auteurs principaux: Tsubouchi, Kazuya, Araya, Jun, Minagawa, Shunsuke, Hara, Hiromichi, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Sato, Nahoko, Yoshida, Masahiro, Kurita, Yusuke, Kobayashi, Kenji, Ito, Saburo, Fujita, Yu, Utsumi, Hirofumi, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Yoshii, Yutaka, Ishikawa, Takeo, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nakayama, Katsutoshi, Nakanishi, Yoichi, Kuwano, Kazuyoshi
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Translational Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584851/
https://ncbi.nlm.nih.gov/pubmed/28613983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1328348
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