PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role in eliminating damaged mitochondria, and is governed by the PINK1 (PTEN induced putative protein kinase 1)-PRKN (p...

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Vydáno v:Autophagy
Hlavní autoři: Araya, Jun, Tsubouchi, Kazuya, Sato, Nahoko, Ito, Saburo, Minagawa, Shunsuke, Hara, Hiromichi, Hosaka, Yusuke, Ichikawa, Akihiro, Saito, Nayuta, Kadota, Tsukasa, Yoshida, Masahiro, Fujita, Yu, Utsumi, Hirofumi, Kobayashi, Kenji, Yanagisawa, Haruhiko, Hashimoto, Mitsuo, Wakui, Hiroshi, Ishikawa, Takeo, Numata, Takanori, Kaneko, Yumi, Asano, Hisatoshi, Yamashita, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Nishimura, Stephen L, Nakayama, Katsutoshi, Kuwano, Kazuyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351145/
https://ncbi.nlm.nih.gov/pubmed/30290714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1532259
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