PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species (ROS) production has been implicated in COPD pathogenesis by accelerating senescence. Mitophagy may play a pivotal role for removal of CS-induced damaged mitochondria, and the PINK1 (PTEN-induced putative kinase...

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Bibliographic Details
Published in:Autophagy
Main Authors: Ito, Saburo, Araya, Jun, Kurita, Yusuke, Kobayashi, Kenji, Takasaka, Naoki, Yoshida, Masahiro, Hara, Hiromichi, Minagawa, Shunsuke, Wakui, Hiroshi, Fujii, Satoko, Kojima, Jun, Shimizu, Kenichiro, Numata, Takanori, Kawaishi, Makoto, Odaka, Makoto, Morikawa, Toshiaki, Harada, Toru, Nishimura, Stephen L, Kaneko, Yumi, Nakayama, Katsutoshi, Kuwano, Kazuyoshi
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Clinical Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502689/
https://ncbi.nlm.nih.gov/pubmed/25714760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1017190
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