Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

Eitemau Tebyg

• Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death
  gan: Kashyap, Trinayan, et al.
  Cyhoeddwyd: (2016)
• Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition
  gan: Azmi, Asfar S., et al.
  Cyhoeddwyd: (2015)
• Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma
  gan: Aboukameel, Amro, et al.
  Cyhoeddwyd: (2016)
• Selective inhibitors of nuclear export for the treatment of non-Hodgkin’s lymphomas
  gan: Azmi, Asfar S., et al.
  Cyhoeddwyd: (2013)
• Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration
  gan: Azmi, Asfar S., et al.
  Cyhoeddwyd: (2017)