Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway

Studies have demonstrated that curcumin (CUR) exerts its tumor suppressor function in a variety of human cancers including head and neck squamous cell carcinoma (HNSCC). However, the exact underlying molecular mechanisms remain obscure. Here, we aim to test whether CUR affects ATM/Chk2/p53 signaling...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, An, Huang, Jing-Juan, Zhang, Jing-Fei, Dai, Wei-Jun, Li, Rui-Lin, Lu, Zhao-Yang, Duan, Jun-Li, Li, Ji-Ping, Chen, Xiao-Ping, Fan, Jing-Ping, Xu, Wei-Hua, Zheng, Hong-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584201/
https://ncbi.nlm.nih.gov/pubmed/28881600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17096
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