Naphthalimides Induce G(2) Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells

Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. The current study was designed to pr...

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Detalhes bibliográficos
Main Authors: Zhu, Hong, Miao, Ze-Hong, Huang, Min, Feng, Jian-Ming, Zhang, Zhi-Xiang, Lu, Jin-Jian, Cai, Yu-Jun, Tong, Lin-Jiang, Xu, Yu-Fang, Qian, Xu-Hong, Ding, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767224/
https://ncbi.nlm.nih.gov/pubmed/19881958
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