Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK...

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Publicado en:F1000Res
Autores principales: Frodyma, Danielle, Neilsen, Beth, Costanzo-Garvey, Diane, Fisher, Kurt, Lewis, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: F1000Research 2017
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583734/
https://ncbi.nlm.nih.gov/pubmed/29026529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.11895.1
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