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Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK...

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Bibliografiske detaljer
Udgivet i:F1000Res
Main Authors: Frodyma, Danielle, Neilsen, Beth, Costanzo-Garvey, Diane, Fisher, Kurt, Lewis, Robert
Format: Artigo
Sprog:Inglês
Udgivet: F1000Research 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583734/
https://ncbi.nlm.nih.gov/pubmed/29026529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.11895.1
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