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Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:F1000Res
Egile Nagusiak: Frodyma, Danielle, Neilsen, Beth, Costanzo-Garvey, Diane, Fisher, Kurt, Lewis, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: F1000Research 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583734/
https://ncbi.nlm.nih.gov/pubmed/29026529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.11895.1
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