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The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of Ras(V12)-Induced and Replicative Senescence
In primary mouse embryo fibroblasts (MEFs), oncogenic Ras induces growth arrest via Raf/MEK/extracellular signal-regulated kinase (ERK)-mediated activation of the p19(ARF)/p53 and INK4/Rb tumor suppressor pathways. Ablation of these same pathways causes spontaneous immortalization in MEFs, and oncog...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1430273/ https://ncbi.nlm.nih.gov/pubmed/16507997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2202-2214.2006 |
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