The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of Ras(V12)-Induced and Replicative Senescence

In primary mouse embryo fibroblasts (MEFs), oncogenic Ras induces growth arrest via Raf/MEK/extracellular signal-regulated kinase (ERK)-mediated activation of the p19(ARF)/p53 and INK4/Rb tumor suppressor pathways. Ablation of these same pathways causes spontaneous immortalization in MEFs, and oncog...

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Main Authors: Kortum, Robert L., Johnson, Heidi J., Costanzo, Diane L., Volle, Deanna J., Razidlo, Gina L., Fusello, Angela M., Shaw, Andrey S., Lewis, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430273/
https://ncbi.nlm.nih.gov/pubmed/16507997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2202-2214.2006
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