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Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD

The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. The aim of this study was to determine the expression and role of phosphatase and tensin homolog deleted from chromo...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Yanagisawa, Satoru, Baker, Jonathan R., Vuppusetty, Chaitanya, Fenwick, Peter, Donnelly, Louise E., Ito, Kazuhiro, Barnes, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582930/
https://ncbi.nlm.nih.gov/pubmed/28522564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00382.2016
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