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EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer’s disease
Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 on AD pathology remain unclear and, in some cases, controversial. In vivo pr...
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| Izdano u: | J Lipid Res |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Biochemistry and Molecular Biology
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5580905/ https://ncbi.nlm.nih.gov/pubmed/28389477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R076315 |
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