EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer’s disease

Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 on AD pathology remain unclear and, in some cases, controversial. In vivo pr...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Tai, Leon M., Balu, Deebika, Avila-Munoz, Evangelina, Abdullah, Laila, Thomas, Riya, Collins, Nicole, Valencia-Olvera, Ana Carolina, LaDu, Mary Jo
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2017
Fag:
Thematic Review Series
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580905/
https://ncbi.nlm.nih.gov/pubmed/28389477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R076315
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