EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer’s disease

Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 on AD pathology remain unclear and, in some cases, controversial. In vivo pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Tai, Leon M., Balu, Deebika, Avila-Munoz, Evangelina, Abdullah, Laila, Thomas, Riya, Collins, Nicole, Valencia-Olvera, Ana Carolina, LaDu, Mary Jo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Thematic Review Series
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580905/
https://ncbi.nlm.nih.gov/pubmed/28389477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R076315
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg