CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

CTLA-4 is a co-receptor that modulates the threshold of T cell activation and autoimmunity. We previously showed that CTLA-4 reverses the TCR-mediated stop signal needed for T cell/APC interactions [Schneider et al., Science 2006, 313: 1972]. In this study, using a different T cell system, we show t...

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Bibliographic Details
Published in:Eur J Immunol
Main Authors: Schneider, Helga, Smith, Xin, Liu, Hebin, Bismuth, Georges, Rudd, Christopher E.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580795/
https://ncbi.nlm.nih.gov/pubmed/18095376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200737423
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