SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation

Despite the importance of the immune adaptor SLP-76 in T-cell immunity, it has been unclear whether SLP-76 directly self-associates to form higher order oligomers for T-cell activation. In this study, we show that SLP-76 self-associates in response to T-cell receptor ligation as mediated by the N-te...

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Hlavní autoři: Liu, Hebin, Thaker, Youg Raj, Stagg, Loren, Schneider, Helga, Ladbury, John E., Rudd, Christopher E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795252/
https://ncbi.nlm.nih.gov/pubmed/23935094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424846
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