The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells

While immune cell adaptors regulate proximal T cell signaling, direct regulation of the nuclear pore complex (NPC) has not been reported. NPC has cytoplasmic filaments composed of RanGAP1 and RanBP2 with the potential to interact with cytoplasmic mediators. Here, we show that the immune cell adaptor...

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Udgivet i:Mol Cell
Main Authors: Liu, Hebin, Schneider, Helga, Recino, Asha, Richardson, Christine, Goldberg, Martin W., Rudd, Christopher E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2015
Fag:
Short Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576164/
https://ncbi.nlm.nih.gov/pubmed/26321253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.015
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