ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

Antigen recognition by the T cell receptor (TCR) directs the assembly of essential signaling complexes known as SLP-76 (also known as LCP2) microclusters. Here, we show that the interaction of the adhesion and degranulation-promoting adaptor protein (ADAP; also known as FYB1) with SLP-76 enables the...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: Lewis, Juliana B., Scangarello, Frank A., Murphy, Joanne M., Eidell, Keith P., Sodipo, Michelle O., Ophir, Michael J., Sargeant, Ryan, Seminario, Maria-Cristina, Bunnell, Stephen C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240300/
https://ncbi.nlm.nih.gov/pubmed/30305305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.215517
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