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Rescue of PreTCR but not Mature TCR Signaling in Mice Expressing Membrane-Targeted SLP-76

SLP-76 (SH2 domain-containing leukocyte phosphoprotein of 76 kDa) organizes signaling from immunoreceptors, including the platelet collagen receptor, the preTCR and TCR, and is required for T cell development. Here we examine a mouse in which wildtype SLP-76 is replaced with a mutant constitutively...

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Библиографические подробности
Главные авторы: Bezman, Natalie A., Baker, Rebecca G., Lenox, Laurie E., Jordan, Martha S., Koretzky, Gary A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727718/
https://ncbi.nlm.nih.gov/pubmed/19380761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802176
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