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Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
Central and peripheral tolerance is required to prevent immune responses to self-antigens. We now present a mouse model in which wild-type (WT) SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) has been constitutively targeted to the membrane, where CD4(+) T cells become spontaneousl...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920203/ https://ncbi.nlm.nih.gov/pubmed/20029045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237438 |
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