Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production

Central and peripheral tolerance is required to prevent immune responses to self-antigens. We now present a mouse model in which wild-type (WT) SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) has been constitutively targeted to the membrane, where CD4(+) T cells become spontaneousl...

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Detalhes bibliográficos
Main Authors: Sonnenberg, Gregory F., Mangan, Paul R., Bezman, Natalie A., Sekiguchi, Debora R., Luning Prak, Eline T., Erikson, Jan, Maltzman, Jonathan S., Jordan, Martha S., Koretzky, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920203/
https://ncbi.nlm.nih.gov/pubmed/20029045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237438
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