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Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 (Lcp2; SLP-76) protects mice from anaphylaxis and arthritis
BACKGROUND: The Src homology 2 (SH2) domain-containing leukocyte phosphoprotein of 76-kilodaltons (SLP-76) is an essential adaptor molecule in myeloid cells, where it regulates FcεRI-induced mast cell (MC) and FcγR- and integrin-induced neutrophil (polymorphonuclear leukocyte; PMN) functions. SLP-76...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778804/ https://ncbi.nlm.nih.gov/pubmed/19895996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.08.038 |
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