Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 (Lcp2; SLP-76) protects mice from anaphylaxis and arthritis

BACKGROUND: The Src homology 2 (SH2) domain-containing leukocyte phosphoprotein of 76-kilodaltons (SLP-76) is an essential adaptor molecule in myeloid cells, where it regulates FcεRI-induced mast cell (MC) and FcγR- and integrin-induced neutrophil (polymorphonuclear leukocyte; PMN) functions. SLP-76...

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Détails bibliographiques
Auteurs principaux: Lenox, Laurie E., Kambayashi, Taku, Okumura, Mariko, Prieto, Christopher, Sauer, Karsten, Bunte, Ralph M., Jordan, Martha S., Koretzky, Gary A., Nichols, Kim E.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778804/
https://ncbi.nlm.nih.gov/pubmed/19895996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.08.038
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