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T cell receptor dwell-times control the kinase activity of ZAP-70
Kinase recruitment to membrane receptors is essential for signal transduction. However, the underlying regulatory mechanisms are poorly understood. We investigated how conformational changes control T cell receptor (TCR) association and activity of ZAP-70 kinase. Structural analysis of ZAP-70 showed...
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| Опубликовано в: : | Nat Immunol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605427/ https://ncbi.nlm.nih.gov/pubmed/26237552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3231 |
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