T cell receptor dwell-times control the kinase activity of ZAP-70

Kinase recruitment to membrane receptors is essential for signal transduction. However, the underlying regulatory mechanisms are poorly understood. We investigated how conformational changes control T cell receptor (TCR) association and activity of ZAP-70 kinase. Structural analysis of ZAP-70 showed...

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Bibliografske podrobnosti
izdano v:Nat Immunol
Main Authors: Klammt, Christian, Novotná, Lucie, Li, Dongyang T., Wolf, Miriam, Blount, Amy, Zhang, Kai, Fitchett, Jonathan R., Lillemeier, Björn F.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605427/
https://ncbi.nlm.nih.gov/pubmed/26237552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3231
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