Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

[Image: see text] Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase. We show that PFL-AE binds a catalytically essential monovalent cation at its active site, yet anothe...

Full description

Saved in:
Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Shisler, Krista A., Hutcheson, Rachel U., Horitani, Masaki, Duschene, Kaitlin S., Crain, Adam V., Byer, Amanda S., Shepard, Eric M., Rasmussen, Ashley, Yang, Jian, Broderick, William E., Vey, Jessica L., Drennan, Catherine L., Hoffman, Brian M., Broderick, Joan B.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579537/
https://ncbi.nlm.nih.gov/pubmed/28768413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b04883
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items