Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

[Image: see text] Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase. We show that PFL-AE binds a catalytically essential monovalent cation at its active site, yet anothe...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Shisler, Krista A., Hutcheson, Rachel U., Horitani, Masaki, Duschene, Kaitlin S., Crain, Adam V., Byer, Amanda S., Shepard, Eric M., Rasmussen, Ashley, Yang, Jian, Broderick, William E., Vey, Jessica L., Drennan, Catherine L., Hoffman, Brian M., Broderick, Joan B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2017
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579537/
https://ncbi.nlm.nih.gov/pubmed/28768413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b04883
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