Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

[Image: see text] Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase. We show that PFL-AE binds a catalytically essential monovalent cation at its active site, yet anothe...

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Publicado en:J Am Chem Soc
Main Authors: Shisler, Krista A., Hutcheson, Rachel U., Horitani, Masaki, Duschene, Kaitlin S., Crain, Adam V., Byer, Amanda S., Shepard, Eric M., Rasmussen, Ashley, Yang, Jian, Broderick, William E., Vey, Jessica L., Drennan, Catherine L., Hoffman, Brian M., Broderick, Joan B.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2017
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579537/
https://ncbi.nlm.nih.gov/pubmed/28768413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b04883
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