Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

Pyruvate formate-lyase activating enzyme generates a stable and catalytically essential glycyl radical on G(734) of pyruvate formate-lyase via the direct, stereospecific abstraction of a hydrogen atom from pyruvate formate-lyase. The activase performs this remarkable feat by using an iron-sulfur clu...

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Main Authors: Vey, Jessica L., Yang, Jian, Li, Meng, Broderick, William E., Broderick, Joan B., Drennan, Catherine L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571006/
https://ncbi.nlm.nih.gov/pubmed/18852451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806640105
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