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Molecular basis of C–N bond cleavage by the glycyl radical enzyme choline trimethylamine-lyase

Deamination of choline catalyzed by the glycyl radical enzyme choline trimethylamine-lyase (CutC) has emerged as an important route for the production of trimethylamine, a microbial metabolite associated with both human disease and biological methane production. Here, we have determined five high-re...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Bodea, Smaranda, Funk, Michael A., Balskus, Emily P., Drennan, Catherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493019/
https://ncbi.nlm.nih.gov/pubmed/27642068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.07.020
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