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Structure-guided identification of a small molecule that inhibits anaerobic choline metabolism by human gut bacteria
The anaerobic gut microbial pathway that converts choline into trimethylamine (TMA) is broadly linked to human disease. Here, we describe the discovery that betaine aldehyde inhibits TMA production from choline by human gut bacterial isolates and a complex gut community. In vitro assays and a crysta...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475491/ https://ncbi.nlm.nih.gov/pubmed/30557011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04883 |
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