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Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community that lacks a single choline-utilizing enzyme. Our results indicate that ch...

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Détails bibliographiques
Publié dans:Cell Host Microbe
Auteurs principaux: Romano, Kymberleigh A., Campo, Ana Martinez-del, Kasahara, Kazuyuki, Chittim, Carina L., Vivas, Eugenio I., Amador-Noguez, Daniel, Balskus, Emily P., Rey, Federico E.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599363/
https://ncbi.nlm.nih.gov/pubmed/28844887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.07.021
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